What does 'abnormal' mean?

In a standard IVF cycle (and I'm still learning here so I may be wrong) it appears that embryo's are graded depending on how well they have grown and the best graded ones are usually put back on day 3.

If an embryo goes to PDG on day 5 as a grade 1 but comes back abnormal what exactly does that mean?

What I'm really trying to get to is: If I did PDG for a girl but all girls came back abnormal, would it ever be worth transferring an abnormal, as in a non-PDG cycle it would have been transferred. 

Has anyone ever transferred an abnormal?

Thank you!

 

http://www.advancedfertility.com/embryoquality.htm I found this site and thought i had useful info, i muself have no idea about ivf, but having had 3 misscarriages and being told most lkely they were caused by an adnormailty, where the cells/baby didnt develop properly, even if they would put back abnormal its probably not a good idea and may lead to heartbreak even if they did grow for a bit, but obviusly i know nothing so dont take my word for it. good luck x

There is a visual inspection and the PGD results.  Even if you just do a 2-probe where they only check for gender, you can still have abnormal embies(XXY, XXX, etc) which would make the embryo abnormal if they do not just see a XX or XY.

There is a member that put back an abnormal and it did take but she miscarried. 

It seems to be that the most likely outcome for putting back an abnormal would be a miscarriage.  Apparently about 90% of miscarriages happen because of chromosomal abnormalities, so I think it's like to lead to a miscarriage.  Or, it's possible that it could lead to the birth of a  disabled child maybe - although i'm just guessing there.  I don't think that I would put in abnormal ones, nor would my Dr. allow it.  i guess that I would rather have a BFN than a miscarriage.  however, I have heard that PGD has at times identified abnormals in embryos that are really healthy, so it's possible that it could work I guess.  I know that there was a gal awhile back who had planned to put an abnormal back because the abnormality was very slight, but I don't think her embyos made it to day 5 anyway, so she didn't get that chance.

Abnormal means there is something wrong with the chromosomes.  I had 3 abnormal females and my doctor would not let me put them back in. 

In a non-pgd cycle, they very well could be put back in.  And most likely miscarry.  Some say that the embryo could correct itself, but I don't think they will ever really know. 

nuthinbutpink:

There is a member that put back an abnormal and it did take but she miscarried. 

 

That was me. 

I could be wrong here but from my understanding most clinics will not allow you to put back an abnormal.

 I agree with the PP. I just had my phone consultation tonight with the reprogenetics institute in Chicago who collaborates with my clinic where I'm cycling in NY (don't ask, I will freak if there is a snowstorm!). Anyway, she said that my doctor wouldn't allow an abnormal embryo to be put back (transfered) b/c it would lead to miscarriage no doubt or other issues.

They offered me a 5 probe or 7-11 probe. We are going with 5 to lessen the chance of a false+++

http://www.geneticsandsociety.org/article.php?id=4758

 

Interesting article. I didn't read this article before deciding to only use 2 probe but becaue of similar ones I decided that 2 probe was the best option for me. It was a good thing too because I didn't have enough embies to go through more.

AMandN:

 I agree with the PP. I just had my phone consultation tonight with the reprogenetics institute in Chicago who collaborates with my clinic where I'm cycling in NY (don't ask, I will freak if there is a snowstorm!). Anyway, she said that my doctor wouldn't allow an abnormal embryo to be put back (transfered) b/c it would lead to miscarriage no doubt or other issues.

They offered me a 5 probe or 7-11 probe. We are going with 5 to lessen the chance of a false+++

 AMand - off topic, but what is the reprogenetics institute in chicago?  is that a main clinic who will do pgd/ivf for gender?  I live there and found one, but doesn't sound like this one......sorry to sound ignorant.  just need someone to hold my hand thru it. 

Does anyone know what increases your chances of abnormals?  I have noticed that some people on here get an awful lot, but maybe thats normal?  Does it have something to do with age, or is it just luck?

A large number of things could increase your chances of abnormals, age is a fairly big factor. 

The thing is IMO, we end up knowing a little too much about the process when doing IVF/PGD.  Falling pregnant naturally isn't all that easy either (even though many of us have been lucky to fall first try...myself included) and abnormals are very common within naturally conceived embryos...many of us would have miscarried at some point and not even been aware that we were pregnant.  The difference with IVF/PGD is that we are mass producing embryos and testing them so we become aware of these chromosomal abnormalities that we would not have otherwise known about. 

I would thing that there are obvious things we could do (both partners) that could potentially decrease our risks of abnormals; ie healthy lifestyle, limiting contact with chemicals, processed things etc but at the end of the day I think it is important accept that it is more than likely that you will encounter chromosomal abnormalities in your cycle.  Last time out of 5 that made it to PGD we had 2 abnormals.

Some people have more abnormals than others...maybe its a luck thing and maybe its just "normal" for them.