Hi Jasmine. I kept mine as cool as possible but did not refrigerate it and I had it in my hand luggage when we flew. I was halfway through explaining to the check-in guy when he just said 'yes, yes thats fine'. No problem at all. Mine was packed in a padded little toiletry bag, I took just enough meds, needles/syringes and swabs. The sharps I took to the clinic to dispose of. Good luck!