UPDATE: Ladies, thank you again for your comments. I took it for a few weeks. The first pill was like switching a light on..it immediately killed my symptoms. Over time, the result was not as strong, but definately effective! One bad side effect: horrible constipation! Friends, if you take zofran, I suggest you greatly increase your fiber along with it and keep milk of magnesia on hand in case of trouble!! Overall, this was a great solution to a terrible time I was having. Good luck to all others struggling with all-day-morning sickness too!!!