I did MS IVF only, no PGD, and got my DD. I chose against PGD because I was worried I'd lose too many embryos due to things like "no signals;" "undetermined," and the general trauma of PGD on the embryo.
It was my third cycle, and I don't make many embyros, and I didn't feel I could spare the loss of any of them. I read a study that showed PGD lowers pregnancy rates. However, this was 5 years ago now, and I know things have improved a lot in the high-tech world since then.
I first started trying high-tech in 1999, when women on boards like these were doing MS IUI and no more; even MS IUI was considered extreme. Then I was one of the "first" to go with MS IVF, which was rare to do, in 2000.
These days, PGD is more commonplace.
Anyway, whatever you do, go with either MS IVF or MS IVF PGD, never PGD alone.